Fantasy baseball lineup advice for Saturday: Take a chance on Kade Anderson in debut

Kade Anderson, the top pitching prospect in baseball, will make his major league debut Saturday against the Cubs. Al Bello/Getty Images

Check out all of our starting pitcher rankings and other lineup selection tools here to help you make smart fantasy baseball lineup decisions. All fantasy advice is geared toward ESPN 10-team leagues with standard scoring.

Note: All information is accurate as of the time of publication. For updates, as well as any breaking news that might impact today's MLB slate, be sure to check out the latest fantasy baseball buzz.


Other resources: RP depth chart | 2026 Rankings
ESPN's 2026 Player Rater | Betting notes for Saturday


Pitchers to stream on Saturday

  • Ryan Weathers is coming off his longest outing of the season, logging 7 1/3 innings in a no-decision last Sunday against the Toronto Blue Jays. The New York Yankees southpaw fanned only four with just one walk, helping to keep his pitch count reasonable. He'll take the hill with five days of rest when he faces the Blue Jays again, this time in the Bronx. Look for another strong effort, though the Blue Jays' approach is putting the ball in play, so Weathers may record another modest strikeout total.

  • Kade Anderson broke most projection systems based on age-adjusted MLEs (major league equivalencies). That's what happens when a 21-year-old posts a 1.06 ERA and 0.64 WHIP with 135 strikeouts in 93 1/3 Double-A innings. As they do with many of their young pitchers, the Seattle Mariners shielded Anderson from Triple-A in the hitter-friendly Pacific Coast League, leaving him with Tacoma. His long-awaited debut comes at home against the Chicago Cubs. The Cubs are potent away from Wrigley Field, but T-Mobile Park is an extreme pitching venue, and Anderson is a special talent.

  • Anderson will be opposed by fellow left-hander David Peterson, though it could come in the form of a bulk reliever role. Peterson was moved to the bullpen, but with Edward Cabrera back on the 15-day IL, the club needs Peterson to again provide length. He'll face a lineup with the second-lowest wOBA and 10th-highest strikeout rate facing lefties.

  • Since being dealt to the Chicago White Sox, Luis Castillo bookended two subpar efforts around a stellar outing. This inconsistency has marred his effort over the past few seasons. The White Sox hope they can work with the right-hander down the stretch, having him produce more efforts like he did in his second start with the club, fanning 10 Cincinnati Reds in seven frames. Next up is a home matchup against the New York Mets. For the season, the Mets sport the fifth-lowest wOBA facing right-handers, but they've been more productive since the break.

  • After struggling in his debut with the San Diego Padres, Casey Mize posted quality starts in his next two outings and is looking for his third straight at home against the Minnesota Twins, a club Mize frequently faced during his tenure with the Detroit Tigers. The Twins were swept by the Philadelphia Phillies last weekend but rebounded by sweeping the Atlanta Braves to begin this week. For the season, they check in with slightly below-average production against righties.

  • Patrick Sandoval is coming off his sole clunker since making his Boston Red Sox debut in early July. That said, he has surrendered a lot of traffic, as shown with a 1.85 WHIP, but he's fanning a batter an inning while keeping the ball in the yard, so his ERA was a palatable 3.30 before his blow-up last time out ballooned it to 4.76. The lefty should send it in the other direction with a favorable home matchup with the San Francisco Giants, who sport the lowest wOBA against left-handers over the past month.

Hitters to stream on Saturday