San Francisco 49ers @ Los Angeles Chargers

Preseason

San Francisco 49ers49ersSF

0-1, 0-0 Away

Los Angeles ChargersChargersLAC

1-0, 0-0 Home

Game Odds
Odds by

2026-08-21T02:00ZOpenSpreadTotalML

San Francisco 49ersSan Francisco 49ersSF

(0-1)

o39.5

-110

Los Angeles ChargersLos Angeles ChargersLAC

(1-0)

-1.5

-110

Recent Schedule

DATE	OPP	RESULT	SPREAD	TOTAL
8/13	vsTEN	L19-13	+6.5	39.5
1/17	@SEA	L41-6	+7	44.5
1/11	@PHI	W23-19	+5.5	44.5
1/03	vsSEA	L13-3	+2.5	48.5
12/28	vsCHI	W42-38	-4.5	51.5

Betting 101

The Beginner's Guide to BettingReady to enter the world of sports betting? Here's everything you need to know to get started.

0-1

1-0

Injury Report

San Francisco 49ers

Name	Status
Brett TothB. TothC	QuestionableConcussion
Dominick PuniD. PuniG	QuestionableConcussion
Sam OkuayinonuS. OkuayinonuDT	QuestionableAnkle
Christian McCaffreyC. McCaffreyRB	QuestionableUndisclosed
Kyle JuszczykK. JuszczykFB	QuestionableFinger

Los Angeles Chargers

Name	Status
Rashawn SlaterR. SlaterOT	QuestionableUndisclosed
Quentin JohnstonQ. JohnstonWR	QuestionableLower Body
Isaiah WorldI. WorldOT	NFI-AKnee
Tyler BiadaszT. BiadaszC	DoubtfulKnee
Luke GrimmL. GrimmWR	QuestionableUndisclosed

Super Bowl Winner

TEAMODDS
LARLAR +550
BUFBUF +1000
BALBAL +1000
SEASEA +1100
KCKC +1600
NENE +1600
PHIPHI +1600
LACLAC +1700

TEAMODDS
GBGB +1800
HOUHOU +1800
DETDET +1900
SFSF +1900
CINCIN +2000
DENDEN +2000
CHICHI +2400
DALDAL +2500

Top Betting Headlines

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Call 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in ONT. Eligibility restrictions apply. Terms: draftkings.com/sportsbook. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL.