The Brumbies have extended their unprecedented winning streak against Australian Super Rugby opposition to 10, with a 43-10 thrashing of the Queensland Reds.

The six-tries-to-one drubbing gave the Canberra-based franchise a bonus point to increase their lead at the top of the Australian conference.

After a sixth-straight defeat, the Reds' season hangs in the balance as their shocking away record continues to hurt them.

A second-half blitz from the Brumbies set up the victory with two converted tries in the first five minutes after the break setting the tone as they went on to pile on 33 unanswered points.

Hooker Robbie Abel scored a try immediately after half-time before a lucky bounce helped fullback Aidan Toua to run more than half the field to score under the posts.

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The match was in the balance at half-time with a James Tuttle penalty goal levelling the scores at 10-all after the siren.

But the 20-year-old halfback, who was promoted to the Reds' starting line-up after coach Nick Stiles dropped Nick Frisby, had earlier cost his side with two missed shots on goal.

The Brumbies victory came at a price with centre Kyle Godwin (broken hand) and back-rower Jordan Smiler (hamstring) suffering match-ending injuries.

They will get the chance to win another derby next week when they face the struggling Rebels in Melbourne, while the Reds host the Kings in Brisbane.