Colts (7-4) at Texans (4-7)
1 p.m. ET | CBS
Matchup rating: 49.3 | Spread: IND -3.5 (50)
What to watch for: Can Colts wide receiver T.Y. Hilton continue to torch the Texans? In 16 career games against Houston, Hilton has 85 catches for 1,537 yards and 10 touchdowns, by far the most against an AFC South team. And despite a slow start, Hilton is coming off his best outing of the season and has a history of big games at NRG Stadium. -- Sarah Barshop
Bold prediction: Houston do-everything defensive lineman J.J. Watt will have his second multisack game of the season. Yes, Colts quarterback Philip Rivers has been sacked only 10 times this season, but there's a chance starting left tackle Anthony Castonzo will miss the game with a knee injury. It's hard enough to stop Watt with a starting tackle. It's really difficult to contain him with a backup. -- Mike Wells
Stat to know: The Texans are averaging 83.9 rushing yards per game this season, 31st in the NFL.
What to know for fantasy: For the season, Houston quarterback Deshaun Watson averages 58.1% more fantasy points per throw to Will Fuller than to all other Texans players. On Monday, Fuller was suspended for six games. See Week 13 rankings.
Betting nugget: Houston is 1-5 against the spread (ATS) against teams with winning records this season, and 3-2 ATS against all others. Read more.
Wells' pick: Colts 27, Texans 23
Barshop's pick: Colts 24, Texans 21
FPI prediction: HOU, 55.2% (by an average of 1.8 points)
Matchup must-reads: No longer No. 1, Colts defense hindered by slow starts ... WR Fuller, CB Roby suspended six games under NFL's PED policy ... Sanchez says surgery to remove tumor "went well" ... What Fuller's suspension means for his future with Texans ... Colts activate sack leader Autry off reserve/COVID-19 list ... Watson: "Very important" that Texans re-sign Fuller